Israel warns "Tehran will burn" if Iran continues firing missiles, while state media say 60 people have been killed in a strike on Iran's capital.

The Middle East has woken to an unprecedented and perilous escalation this morning, as Israel launched a large-scale military operation against Iran, targeting critical nuclear facilities, military installations,

Chatham House experts offer immediate reaction following Israeli strikes against the Iranian military and nuclear facilities. How will Iran, the US, the UK and Iranian allies respond?

Republicans and some Democrats offered strong support for Israel’s move, but many Democrats called for de-escalation and warned of the consequences of a broader war.

Pakistan has condemned the unprovoked Israeli assault on Iran, calling it an "unacceptable violation of international law" after Tehran's nuclear and military facilities were targeted early morning on Friday that resulted in the deaths of Iranian nuclear scientists and the military's top officials.