Hundreds of civilians, mostly in Iran, have been killed by dueling airstrikes despite international pleas for de-escalation.

Israel hit more targets in Tehran and Iranian missiles fired at Israel killed at least 14, as the conflict entered a third day

The retaliatory strikes came on Saturday, a day after Israel killed top Iranian military leaders and scientists and destroyed an aboveground nuclear enrichment plant near Natanz.

The Israeli military has damaged critical nuclear infrastructure and killed scientists, but Tehran’s most formidable enrichment plant remains.

Israel and Iran have opened a new chapter in their long history of conflict when Israel launched a major attack with strikes early Friday on Tehran.

Israel and Iran kept up their attacks, killing and wounding civilians and raising concern among world leaders meeting in Canada this week that the biggest battle between the two old enemies could lead to a broader regional conflict.

Israel was exploiting its advantage, saying it had taken out dozens of surface-to-air missiles in western Iran and killed the intelligence chief of the Islamic Revoluti