The San Francisco 49ers resume their quest for the No. 1 seed in the NFC West - yes, seriously - by facing the Tennessee Titans, who are tied for the worst record in the NFL.

The San Francisco 49ers made a major change to their injury report on Saturday ahead of their Week 15 matchup with the Tennessee Titans.

The Tennessee Titans and the San Francisco 49ers meet Sunday in Week 15 in Santa Clara, California, with kickoff slated for 4:25 p.m. ET.

Preview the Week 15 matchup between the San Francisco 49ers and Tennessee Titans with predictions, odds, over/under, spread, betting lines and more.

Our experts' predictions are in for Tennessee Titans vs. San Francisco 49ers on Sunday. Here's who our experts are picking to win the Week 15 NFL game.

One of the main areas the Tennessee Titans have struggled in this year revolves around their run game. Running back Tony Pollard has been a shell of himself, bu

The Tennessee Titans have been rumored to be eyeing former Dallas Cowboys head coach Mike McCarthy as their replacement for the fired Brian Callahan, but it's reportedly not guaranteed they'll pursue him.

USA Today's NFL experts make their picks for a Week 15 showdown between the San Francisco 49ers and Tennessee Titans

The Tennessee Titans dipped into their practice squad to add some reinforcements for their Week 15 matchup with the San Francisco 49ers.