The 49ers have struggled against the run recently, in large part because of injuries to their front seven. San Francisco has given up more than 135 yards rushing in each of the past two games and has allowed teams to average 5.4 yards per carry over the last three.

The Indianapolis Colts' 2025 season was dealt a devastating blow on Sunday after quarterback Daniel Jones was lost for the season with a torn Achilles. Now, the focus is on Anthony Richardson and when he might come back from his own injury.