Researchers have discovered how cells activate a last-resort DNA repair system when severe damage strikes. When genetic ...

DNA Repair Pathways in Clinical Practice: Lessons From Pediatric Cancer Susceptibility Syndromes. If you have the appropriate software installed, you can download article citation data to the citation ...

The researchers focused on Fanconi anemia, a rare inherited disorder characterized by a failure to repair specific types of DNA damage. In this condition, the two strands of DNA literally become stuck ...

A new study published in Science Translational Medicine by researchers at The University of Texas MD Anderson Cancer Center ...

Despite the significance of immune checkpoint inhibitors (ICIs) in solid tumor treatment, identifying ICI-sensitive populations remains a challenge. Mutations in DNA damage response (DDR) pathway ...

An elegant collaboration between researchers in the UK's two core-funded Medical Research Council Research Institutes, the Laboratory of Medical Sciences (LMS) in London and the Laboratory of ...

A new study in fruit flies describes how an animal’s gut reacts differently to beneficial microbes versus harmful pathogens. A pathway known for repairing damaged genetic material, called the ...

Rare inherited genetic variants significantly increase familial lung cancer risk, offering new targets for early detection.