Causal mediation analysis comprises a set of statistical techniques designed to disentangle the pathways through which an exposure or treatment exerts its effect on an outcome. By partitioning the ...

Over the past few months more healthcare articles have featured a new (at least for me) statistical methodology: mediation analysis. It doesn’t prove causality, but it can assign a value to the impact ...

Background: Mediation analysis addresses the question of the mechanisms by which an exposure causes an outcome. This article is intended to convey basic knowledge of statistical mediation analysis.

Nintedanib treatment reduces the levels of circulating cancer antigen 125 in patients with progressive pulmonary fibrosis.

A new guideline has been developed to help scientists publish their research accurately and transparently. Published in JAMA, the AGReMA Statement (A Guideline for Reporting Mediation Analyses) ...

(A) Represents mediation model 1: subjective cognitive complaints as the dependent variable (Y), the average MD as the independent variable (X), and the average cortical thickness as the mediator (M); ...