These findings are important as they show that affected muscles in an ALS mouse model remain receptive to reinnervation by healthy engrafted motor neurons, even until the late stages of the disease.

A research group conducted experiments using aged mice to demonstrate that muscle denervation at the neuromuscular junction (NMJ, *1) could be appreciably offset by an NMJ formation-enhancing ...

Treatment with Evrysdi (risdiplam) may modestly improve arm function for adults with spinal muscular atrophy (SMA), a new study indicates.

Some patients with later-onset spinal muscular atrophy (SMA) type 2 and type 3 had improved motor function when the investigational monoclonal antibody apitegromab was added to their treatment, the ...

You may already be familiar with ALS, especially if you took part in the viral ice bucket challenge to raise awareness of the ...

The blood creatinine-to-cystatin-c ratio may be a biomarker of Spinraza treatment response in children with SMA, a study in ...

“Instead of inserting the corrected piece of information, we used CRISPR to cut DNA in two strategic places,” study coauthor Dwi Kemaladewi, a research fellow at the Hospital for Sick Children (Sick ...

Amyotrophic lateral sclerosis, or ALS, attacks nerve cells known as motor neurons in the brain and spinal cord, gradually leading to paralysis. The loss of function of an important gene, C9orf72, may ...

The obturator nerve is a large, multibranched nerve that travels through your pelvis to your inner thigh. This nerve helps you feel sensations like temperature and pain in your lower limbs. It also ...

Walking after age 60 helps, but experts reveal that lifting weights protects strength and independence in the long term.