Curt Cignetti's history against Penn State goes back decades, making Saturday's thrilling comeback victory extra special.

The No. 2 Indiana Hoosiers take a trip to Happy Valley to visit the Penn State Nittany Lions Saturday. Kickoff is at noon ET.

Indiana Hoosiers quarterback Fernando Mendoza (15) runs with the ball while being pressured by Penn State Nittany Lions safety Zakee Wheatley (6) during the third quarter Saturday at Beaver Stadium in University Park, Pa. (Matthew O'Haren/Imagn Images)

Here's a look at picks, predictions and odds for every game involving a top-25 team during Week 12 of the college football season:

The Hoosiers are 14.5-point favorites in the latest Indiana vs. Penn State odds, while the over/under for total points scored is 49.5, down a point from the opener. Before making any Indiana vs. Penn State picks,

Vaughn Dalzell breaks down his five bets bets for the week including Indiana at Penn State, Oregon traveling to Iowa, and more!

COLUMBUS, Ohio (AP) — Julian Sayin passed for 316 yards and four touchdowns, Jeremiah Smith scored twice and top-ranked Ohio State pulled away in the second half to defeat Penn State 38-14 Saturday. The Buckeyes (8-0, 5-0 Big Ten) had a 17-14 lead at halftime, but took control in the second half, scoring on three of their first four possessions.

The Indiana Hoosiers face the Penn State Nittany Lions in a Week 11 college football game. Follow along for live updates.