Human and animal cells are compartmentalized by several different membrane-bound entities called organelles, each responsible for specific cellular tasks. Until now, it was unclear how the individual ...
The cytoplasm of eukaryotic cells is elaborately subdivided into membrane-bound compartments called organelles, each precisely tailored for a defined set of biochemical reactions. Cells must maintain ...
Endosomal stress, the aberrant accumulation of K63 ubiquitin chains on dysfunctional endosomes, activates the TAB2/3–TAK1–NF-kB and p62–Keap1–Nrf2 pathways, resulting in the expression of immune and ...
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