Nature

A Mendelian randomization study on the effects of plasma lipids on irritable bowel syndrome and functional dyspepsia

Although functional gastrointestinal disorder (FGID) is a common clinical condition, its risk factors remain unclear. We performed a Mendelian randomization study to explore the association between ...
Nature

Mendelian randomization study reveals causal effects of specific gut microbiota on the risk of interstitial cystitis/bladder pain syndrome (IC/BPS)

Interstitial cystitis (IC), also known as bladder pain syndrome (BPS), manifests as chronic pelvic pain that is primarily associated with bladder (pain, pressure, discomfort) and is accompanied by ...
Managed Healthcare Executive

VA’s holistic approach for chronic pain beats CBT, study finds

Randomization across six VA health systems (Sept 2020–Jan 2024) assigned 764 veterans with chronic pain to Whole Health, ...
The New England Journal of Medicine

Community-Based Cluster-Randomized Trial to Reduce Opioid Overdose Deaths

Evidence-based practices for reducing opioid-related overdose deaths include overdose education and naloxone distribution, the use of medications for the treatment of opioid use disorder, and ...
ascopubs.org

Bayesian Adaptive Randomization: Full of Promise With a Helping of Caution

Poly(ADP-ribose) Polymerase Inhibitor Combinations in First-Line Metastatic Castration-Resistant Prostate Cancer: Increasing Toxicity With Unclear Benefits In the article that accompanies this ...
The New England Journal of Medicine

Prehospital Whole Blood in Traumatic Hemorrhage — A Randomized Controlled Trial

Whole-blood transfusion has recently gained favor in the management of severe hemorrhage; however, data from large clinical trials evaluating its clinical effectiveness and safety are lacking. We ...