Effects of c-Myc overexpression on the DNA damage-induced G2/M checkpoint were studied in finite lifespan, normal human mammary epithelial cells (HMECs). Previously, we showed that c-Myc attenuates G1 ...

Figure 1: Chronic induction of c-MYC in the mammary epithelium of MTB/TOM mice results in reversible hyperplastic lesions. We injected mice with 1 mg BrdU per 20 g body weight 2 h before killing.

Researchers have determined the mechanism used by c-Myc to increase the expression of all active genes in cancer cells. Elevated levels of c-Myc are linked to increased rates of metastasis, disease ...

Asymmetric cell division plays an important role during the development of our nervous and digestive systems. It is thought that T cells, a type of immune cell, can also divide asymmetrically, giving ...

The c-Myc oncoprotein is frequently overexpressed in human cancers and is essential for cancer cell proliferation. The dysregulation of ubiquitin-proteasome-mediated degradation is one of the ...

The c-myc gene is commonly activated in a variety of human tumors. As a new report in the October 1 issue of Genes & Development shows, scientists are gaining a better understanding as to why. Dr.

Preliminary safety and activity of perioperative triplet chemotherapy plus bevacizumab (bev) in patients with borderline resectable colorectal cancer liver metastases (CLM). Final phase II trial ...

Scientists at the Karolinska Institutet in Sweden have found a new region in the c-Myc oncogene that would allow the development of a binding compound to target it. Their discovery is based on a ...

Myc is one of the most frequently mutated, widely studied, and overexpressed genes implicated in cancer. Most mutations in the myc gene lead to its constitutive expression. The myc gene codes for the ...

Scientists have long known that in tumor cells, elevated levels of MYC’s protein product, c-Myc, are associated with poor clinical outcomes, including increased rates of metastasis, recurrence, and ...