Aging is a major risk factor for chronic diseases, and calorie restriction (CR) is a robust non-pharmacological intervention ...

RNA splicing involves the removal of non-coding introns and the joining of coding exons in precursor mRNA (pre-mRNA) to produce mature messenger RNA (mRNA). Splicing changes can lead to diseases, ...

Aging is a major risk factor for chronic diseases, and calorie restriction (CR) is a robust non-pharmacological intervention that can extend health ...

Researchers at the Centre for Genomic Regulation (CRG) have created the first blueprint of the human spliceosome, the complex molecular machine that edits genetic messages transcribed from DNA, ...

Although the participation of spliceosomes is almost always required for intron removal, a few types of genes have self-splicing RNA introns.