AbstractIntroduction:. Ikaros family zinc finger protein 1 and 3 (IKZF1/3) are essential transcription factors (TF) for the differentiation of B and T lymphocytes. IMiDs (e.g. pomalidomide, CC-220, CC ...

Integrative genetic analyses and functional studies in extranodal NK/T-cell lymphoma identify frequent disruptions of X-linked drivers, reveal prognostic molecular subgroups, and uncover recurrent MSN ...

ActA mediates cross-talk between breast cancer cells and cancer-associated fibroblasts in the lung metastatic niche that enhances fibrosis and metastasis, implicating ActA as a potential therapeutic ...

Cancer Res (2021) 81 (13_Supplement): 1261.

Cancer Discov (2026) 16 (1): OF1.

1Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California. 2Cancer Institute, Stanford University School of Medicine, Stanford, ...

1Department of Oncology, University of Lausanne, Lausanne, Switzerland.

1Division of Cancer Prevention, National Cancer Institute, NIH, Rockville, Maryland. *Corresponding Author: Sudhir Srivastava, Cancer Biomarkers Research Group, Division of Cancer Prevention, National ...

The discovery and characterization of novel WRN helicase inhibitors provides pharmacological validation for the clinical development of WRN inhibitors for the treatment of patients with MSI tumors.

Increased yes-associated protein transcriptional activity stimulated by loss of Ku70 induces PARP1 degradation by upregulating SMURF2 to inhibit DNA damage, driving genome instability and ...

Abstract. Binding of steroid hormones to their cognate receptors regulates the growth of most prostate and breast cancers. We hypothesized that CYP11A inhibition might halt the synthesis of all ...

Cancer Res (2023) 83 (7_Supplement): 526. RMC-9805 treatment caused selective and persistent modification of KRAS G12D leading to deep and durable suppression of RAS pathway activity, inhibition of ...