The Ohio-based biotech entrepreneur has emerged as a leading contender to succeed Vice President-elect JD Vance in the U.S. Senate.

Gov. Mike DeWine must pick someone to replace Vice President-elect JD Vance, who resigned his Senate seat last week.

Neither Lara Trump nor Vivek Ramaswamy will join the Senate. But it’s likely the president-elect didn’t really go to the mat for their appointments.

Ramaswamy’s remarks on the H-1B program drew from his personal experience. The son of Indian immigrants who came to the U.S. on work visas, he excelled academically, becoming valedictorian at St. Xavier High School in Cincinnati. His upbringing informed his critique of American culture, which he believes undervalues hard work and innovation.

Ohio Gov. Mike DeWine’s frontrunner for the vacancy is Lt. Gov. Jon Husted — not Ramaswamy, Republican operatives told The Post.

President-elect Donald Trump has privately encouraged Vivek Ramaswamy to consider an appointment to the US Senate seat recently vacated by Vice President-elect JD Vance if offered the position by Ohio Gov.

Gov. Sarah Huckabee Sanders and 25 other Republican governors support President-elect Trump's "appointment of Elon Musk and Vivek Ramaswamy and agree with their assertion that the federal government needs to be cut down to size,

Speaker Mike Johnson is facing bipartisan backlash for removing GOP Rep. Mike Turner as House Intelligence Committee Chair. Also, Vivek Ramaswamy has emerged as a prospect for JD Vance’s Ohio Senate seat.

The entrepreneur will continue leading Donald J. Trump’s government efficiency project before turning his attention to a campaign. He has encountered some turbulence with Mr. Trump, and with Elon Musk.