Florio’s pick: 49ers 27, Seahawks 24. Simms’s pick: Seahawks 27, 49ers 17. The Texans’ defense is on par with other great units that carried the franchise to a Super Bowl win. This week, they likely won’t have to overcome a surprisingly poor performance from quarterback C.J. Stroud.

The Seattle Seahawks and San Francisco 49ers will square off for the second time in a three-week span on Saturday night, though this battle between the two NFC West foes feels different. The Seahawks are coming off a bye after earning the No.

The NFL has never experienced a playoff weekend quite like this. The first four games of the 2025 postseason featured a combined 12 lead changes in the fourth quarter, topping the record for the most in an entire playoffs.