The Quesadilla Co. opened Nov. 23 at 6230 Shimer Road, Lockport, formerly a Ted’s Hot Dogs. The restaurant, developed by ...

It is rare for babies to be born with syphilis. During a typical year, the number of babies born with syphilis in Erie County ...

The Buffalo Sabres host the Winnipeg Jets after Tage Thompson's two-goal game against the Colorado Avalanche in the Sabres' 5-4 loss ...

Buffalo mayoral candidate Garnell Whitfield sits down to talk about bringing change, addressing housing issues, and ...

President and CEO of Buffalo Museum of Science Gary Siddall and Dr. Holly Schreiber joined Most Buffalo in studio Tuesday to ...

Lake Effect Snow Warnings go up again later tonight and last into Friday south of Buffalo into Ski Country. Another 1 to 2 ...

The Great Lakes experienced a surge of activity as arctic air passed over record-warm waters, generating prolific snowfall.

Nathan MacKinnon scored twice as the visiting Colorado Avalanche rattled off five unanswered goals for a come-from-behind 5-4 ...

The New York State Thruway Authority is reminding drivers to move over for workers after sharing a video of a tractor-trailer ...

The Erie County Legislature amended County Executive Mark Poloncarz's proposed 2025 budget on Tuesday by cutting eight new full-time positions and trimming projected fringe benefit costs for employees ...

The San Francisco 49ers have signed a former New York Jets running back to replace the injured Christian McCaffrey and Jordan ...

The New York State Thruway Authority is asking drivers to slow down and move over after a tractor-trailer hit an attenuator ...