Huntington’s disease (HD) is caused by an expansion of the DNA code, a repeated C-A-G letter stretch within the huntingtin ...

This gene contains the instructions for making the huntingtin proteinhuntingtin protein The protein produced by the HD gene..

6 min read | A new study suggests that reduced awareness of symptoms, known as anosognosia, may appear even in the earliest ...

Among the problems faced by people with Huntington’s disease (HD), a common one is weight loss. Many individuals with the disease lose weight over time, even when they are trying to eat enough. This ...

Today, Roche announced in a community letter difficult news for the Huntington’s disease (HD) community, discontinuing two separate clinical programmes after new data emerged from ongoing studies. The ...

Huntington’s disease (HD) involves the loss of cells in the striatum, an area of the brain that plays important roles in movement, cognition, and behaviour. For decades, researchers have been ...

A new study shows that lowering a harmful piece of the huntingtin message (Htt1a) appears effective at reducing HD-related symptoms in mice, perhaps more so than targeting full length HTTHTT one ...

⏱️ 5 min read | A recent study suggests that strengthening the brain’s own clean-up system could slow Huntington’s disease. Cells in our body have a trash-disposal system to remove any damaged or ...

Skyhawk Therapeutics shared results for SKY-0515, a drug designed to lower huntingtin. The drug appeared generally safe, with 60% reduction of huntingtin in blood at the highest dose tested. This data ...

⏱️ 9 min read |New research in a HD mouse model points to a key culprit: a small fragment called HTT1a. Lowering HTT1a levels successfully delayed disease signs in mice that model HD, perhaps shaping ...

A new collaboration between researchers at Indiana University Southeast and Bellarmine University in Kentucky, both in the USA, aimed to investigate what happens when a physical therapist and a music ...

Scientists used cells from a person with Huntington’s disease (HD) to test whether lowering the levels of DNA repair genes can slow the growth of the nefarious CAG repeatCAG repeat The stretch of DNA ...