Objective To apply large language models (LLMs) to Reddit posts referencing SLE to identify patient-expressed unmet medical ...

Objectives To determine the prevalence of cerebral atrophy in a multi-ethnic systemic lupus erythematosus (SLE) cohort and to ...

Introduction Patients with SLE have an increased risk of infections and infection-related mortality, which may be associated ...

Introduction Cognitive symptoms such as ‘brain fog’ are frequent and disabling in patients with SLE. We aimed to develop and ...

Objective SLE is a chronic autoimmune disorder with a range of symptoms. While these are broadly reported in the literature, the symptom impact of SLE on patient health-related quality of life is less ...

Background Janus kinase inhibitors (JAKis) are emerging therapies for SLE, but concerns regarding thromboembolic risk persist. Clinical trials in SLE have not consistently demonstrated an increased ...

Background Lupus nephritis (LN) is a devastating complication of systemic lupus erythematosus (SLE). Aberrant IgG glycosylation drives podocyte injury and is a robust marker for LN. The primary method ...

Objective While guidelines advocate renin-angiotensin system inhibitors (RASi) for renoprotection in lupus nephritis (LN), evidence is largely extrapolated from non-lupus populations. Evidence ...

Introduction Antiphospholipid syndrome (APS) is a systemic autoimmune disorder marked by thrombotic and non-thrombotic manifestations. In children, diagnosis remains challenging due to lack of ...

Objective Hydroxychloroquine (HCQ) is a cornerstone therapy for SLE, reducing flares, organ damage and mortality. However, weight-based dosing yields highly variable drug exposure, which can result in ...

Objective To investigate the association between anti-ribonucleoprotein (anti-RNP) antibodies and endothelial dysfunction (ED) in patients with SLE and their ability to predict early ED manifestations ...

Objectives SLE is characterised by unpredictable flares and periods of quiescence. Currently, the mechanisms driving flares remain incompletely understood. Type I interferon (IFN) signalling is ...