Trontinemab has done it again. This time, in an open-label extension. As presented at the Alzheimer’s Association International Conference held July 12 to 15 in London, the brain-shuttled antibody ...
The field now has more evidence that tightening the tau spigot may slow Alzheimer’s progression. At this year’s Alzheimer’s Association International Conference, held July 12–15 in London, Catherine ...
As more people with Alzheimer’s disease start taking anti-amyloid drugs, research studies will have to adjust. At the Alzheimer’s Association International Conference, held in London July 12-15, ...
Two new ApoE variants turned up in American populations. Protective variant W276C discourages ApoE from oligomerizing. Risk variant R189C promotes its lipidation. Lipidated ApoE4 disrupts microglial ...
Unlike for Alzheimer's disease, which can be diagnosed with the help of a growing suite of FDA-approved blood and cerebrospinal fluid (CSF) tests, clinicians have no easy way to diagnose or monitor ...
The family tree of tau filament folds continues to sprout new branches. With them come new questions. At the Tau Global Conference, held May 14-15 in Washington, D.C., scientists grappled with the ...
Can brain amyloid reduction be used as a surrogate biomarker of clinical benefit? This is a hotly debated question in the field (see Dec 2024 discussion). A recent post hoc analysis of Phase 3 ...
Sit down, brain—a different organ takes the mic in a new study on the Christchurch variant of ApoE3. In the May 6 Neuron, scientists report that the liver cleared more brain amyloid when it produced ...
White-matter hyperintensities, a sign of damage to the brain’s vasculature, are common on MRI scans of people with Alzheimer’s disease. Do they indicate an independent vascular co-pathology, or are ...
During five 11-hour days in Copenhagen, Denmark, nearly 6,000 attendees soaked up talks and posters at the 20th International Conference on Alzheimer’s and Parkinson’s Diseases. From March 17-21, ...
Amyloid plaques drive the spread of tangles throughout a person’s brain, but much about this process remains mysterious. At this year’s AD/PD conference in Copenhagen, Denmark, speakers showed PET ...
The notion that lithium might treat Alzheimer’s was revived last year when scientists reported that the brains of people and mice with amyloid pathology are deficient in the metal ion, and that the ...
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