“Disclosure Day” is upon us. Steven Spielberg’s latest, which follows a whistleblower (Josh O’Connor) and a TV weatherwoman (Emily Blunt) on a desperate quest to expose the truth about ...

An illustration of a G protein–coupled receptor (purple) nested in a cell membrane (white and blue). GPCRs’ location in the cell membrane makes their binding pockets difficult to reach. Credit: ...

Many scientists first encountered G protein–coupled receptors (GPCRs) as a looping sketch across the cell membrane in an early biology textbook. That simple diagram belied the complexity of a receptor ...

G protein-coupled receptors, or GPCRs, sit in the plasma membrane, the boundary that defines the inside and outside of a living cell. They communicate with nearly every physiological process in our ...

Be careful what you wish for. This idea, often explored in fiction, lies at the center of “Obsession,” Focus Features‘ new horror film from writer/director/editor Curry Barker. The movie follows Bear ...

This lesson was created by Rebecca Brewer, a biology educator in Troy, Michigan, as part of the fall 2025 Pulitzer Center Teacher Fellowship program. It is designed for facilitation across ...

Scientists have identified a little-known receptor, GPR133, as a powerful regulator of bone strength. By activating it with a newly discovered compound called AP503, they were able to boost bone ...

Adhesion GPCRs are a large class of surface proteins that recognize chemical and mechanical stimuli in the body. The rapidly expanding body of knowledge on the therapeutic targeting of these receptors ...

Opioid receptors are fantastic targets for treating pain—but unfortunately, the drugs that target them can be addictive. Because the molecules suppress breathing and heart function, those drugs can ...

New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and "molecular glues" can rewire G protein-coupled receptor (GPCR) signaling, ...

A study headed by researchers at the Centre for Genomic Regulation (CRG) in Barcelona has provided for the first time evidence that a single drug, already licensed for medical use, can stabilize ...