Researchers at Michigan Medicine report a potential new therapeutic target for gastrointestinal neuroendocrine tumors: a vulnerability in how these cancer cells handle iron and fat metabolism. In ...

Lysosomes were once viewed mainly as cellular waste disposers, but are now recognized as key hubs for nutrient sensing and metabolic signaling. Still, what lysosomes contribute metabolically inside ...

Stanford researchers constructed an atlas of the proteins found in the lysosome across different brain cell types, a recently published paper reported. Lysosomes are cell organelles that play ...

Summary: Why do some people with a genetic risk for Parkinson’s disease remain healthy while others develop debilitating symptoms? Researchers at discovered that it takes two “partners in crime” to ...

Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease, affecting more than 10 million people worldwide. The disorder is characterized by progressive ...

What makes synapses disappear with age? In the January 21 Nature, scientists led by Tony Wyss-Coray at Stanford University School of Medicine, California, report that sluggish turnover of synaptic ...

The start-up Function will send practically anyone to a lab for extensive medical testing, no physical required. Is that a good thing? By Kristen V. Brown As Kimberly Crisp approached middle age, ...

Common variants in the phosphoinositol phosphatase INPP5D are linked to an increased risk of late-onset Alzheimer’s disease, but no one is quite sure why. Recent work suggests that depleting INPP5D in ...

This article and associated images are based on a poster originally authored by Teresa Sorbo, Manuel Paina, Manuel Arcangeletti, Katja Blasi, Sara Martin, Donatella Bardelli, Paola Picardi, Fernanda ...

In the Wang Lab, it's not unusual for worms to live for a long time. HHMI Janelia Research Campus Senior Group Leader Meng Wang and her team study longevity. They've shown that by overexpressing an ...

Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...