The 49ers just lost their second game in a row by at least 25 points for the first time since Jim Tomsula was the head coach.

The 49ers lost their third straight game on Sunday to fall to 5-7 as the team's remarkably disappointing season continues.

The San Francisco 49ers are in dire straights after a blowout loss to the Buffalo Bills, and QB Brock Purdy knows it.

See what Kyle Shanahan, Brock Purdy, Sean McDermott and Josh Allen had to say following the Week 13 primetime contest.

Sunday after the 49ers lost their seventh game, I asked Brock Purdy to make of the terrible season the 49ers are having. Here ...

This has led to a profound resource drain to the 49ers. They kept up their turn-and-burn roster approach of letting guys ...

Head coach Kyle Shanahan shared the latest injury and team updates emerging from the San Francisco 49ers Week 13 matchup ...

The weather outside was frightful at Highmark Stadium in Orchard Park, New York on Sunday night, but the way the San ...

The 49ers were absolutely shellacked Sunday for a second straight week as the Buffalo Bills beat them 35-10 on national ...

Before the 2024 NFL season, Sunday night's Week 13 matchup between the Buffalo Bills and San Francisco 49ers might've been ...

Temperatures reached the 20s Sunday night as snow fell throughout Buffalo’s Week 13 home game against San Francisco. For the ...

After struggling mightily without Brock Purdy this past Sunday, the 49ers will be waiting with bated breath to see if their starting QB will play. San Francisco head coach Kyle Shanahan isn’t ...