NFL Week 16 odds, picks, predictions, TV channel, streaming information for Monday Night Football between San Francisco 49ers and Indianapolis Colts.

Despite losing to the Seattle Seahawks on Sunday in his first start since the 2020 season, Indianapolis Colts veteran quarterback Philip Rivers will get his chance at redemption.

The Indianapolis Colts are staring at one of the most delicate quarterback decisions of their season, and the national commentary has already begun backing one direction. ESPN’s Dan Orlovsky didn’t hesitate this week when asked who should start for Indianapolis in Week 15.

Jonathan Taylor has had a magnificent season for the Colts, but he's about to run into a brick wall that is Seattle's run defense.

The Indianapolis Colts are expected to start 44-year-old Philip Rivers on Sunday against the Seattle Seahawks, after he was elevated from the practice squad to the 53-man roster.

The Colts made waves by signing Rivers, who has not played in the NFL since 2020, to their practice squad earlier in the week. They have officially activated him to the 53-man roster and intend to start him in Week 15, ESPN's Adam Schefter reported.

The Indianapolis Colts may soon have another option at quarterback following the signing of 44-year-old Philip Rivers.

The Colts are getting one of their quarterbacks back for football activity. Here's what it means after Philip Rivers was signed and started.

Daniel Jones' Achilles tear shouldn't affect his standing as the Indianapolis Colts' quarterback of the future, according to Jay Glazer.

The Indianapolis Colts vs. Seattle Seahawks game kicks off at 4:25 p.m. ET/1:25 p.m. PT on Sunday, Dec. 14, 2025. The Week 15 game between the Colts and Seahawks will air in local markets on CBS, which means if it's on in your area, it'll also stream live on Paramount+. You can also tune in on mobile devices with NFL+.