Transferrin-receptor shuttles distribute antibody cargo throughout the parenchyma, steering clear of ARIA-provoking vascular amyloid. Trontinemab is enrolling Phase 3 for early AD, announces plans for ...

The field now has more evidence that tightening the tau spigot may slow Alzheimer’s progression. At this year’s Alzheimer’s Association International Conference, held July 12–15 in London, Catherine ...

As more people with Alzheimer’s disease start taking anti-amyloid drugs, research studies will have to adjust. At the Alzheimer’s Association International Conference, held in London July 12-15, ...

Somewhere, a synapse fires. Sodium and calcium flood the dendrite and trigger transcription of genes necessary for learning and memory. Within minutes, the transport protein Arc reaches the dendrite ...

Turns out, microglia need TDP-43 to properly shape the brain's white matter during development. In the July 8 Nature Neuroscience, scientists led by Rosa Paolicelli at the University of Lausanne, ...

Building 114, Suite 2011 16th Street Charlestown, MA02129 United States Visit Website Contact: Bradley T. Hyman, M.D., Ph.D. Phone: (617) 726-3987 E-mail: bhyman@partners.org Brain Banks Home ...

At AAIC, Biogen presented diranersen data. Despite missing its endpoint, the drug showed enough target engagement and cognitive benefit to go to Phase 3.

The center collects, processes, stores, and distributes samples, including longitudinal samples, from its research participants. Collections are taken from donors in their 40s to late 90s in a limited ...

Funding Level 1: $0.3M total costs. Funding Level 2: $1.0M total costs. Pre-Application (Letter of Intent) Submission Deadline: 5:00 p.m. Eastern Time (ET), October ...

Microdissection of more than 130 different brain nuclei is performed on frozen brains. These samples are approved for neurochemistry, neuroendocrine, molecular biology, proteomic and genomic studies.

The center accepts brain donations from Alzheimer's patients and cognitively normal controls who were seen at the center before death (family members can call the office to discuss feasibility of ...

In the quest to understand how APOE4 heightens the risk of Alzheimer’s disease, scientists are drilling down to nuances such as how the variant acts in women versus men, and how it affects cell types.