Arizona Cardinals running back Trey Benson, sidelined since late September with a knee injury, will not return this season. Head coach Jonathan Gannon confirmed that the team will not activate Benson from injured reserve before his 21-day practice window expires Wednesday.

Now, add to that list Trey Benson, who has missed most of the season anyways with a knee issue, but now he will be done for the year with no chances to come back, as his 21-day practice window closed today. Trey Benson will NOT be activated the rest of the season @PHNX_Cardinals pic.twitter.com/3iikuh7MWQ

Trey Benson might not get to play for the remainder of the 2025 season after suffering a setback during his recovery from a knee injury. The running back has been sidelined since Week 4.