What causes Duchenne Muscular Dystrophy? Duchenne is a genetic condition caused by a change in the gene that makes dystrophin. Dystrophin is a vital protein found in every muscle in the body. It acts like a shock absorber, protecting muscles as they contract and relax during everyday movement. When dystrophin is missing, muscles become fragile. Normal daily activity can cause tiny tears in the muscle cells. Without dystrophin, those tears can’t be repaired. These micro-injuries allow calcium to
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Duchenne muscular dystrophy (DMD) is a devastating genetic condition that results in progressive muscle weakness, spinal deformities, heart failure and early mortality. While genetic therapies are being explored, current treatments only alleviate symptoms. However, MCW’s Dr. Brian Lin and his lab are researching a promising approach that examines a calcium channel which becomes hyperactive in DMD and how inhibiting that channel could counteract the leading cause of death in DMD patients. Learn m
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